Elevated inflammatory gene expression in intervertebral disc tissues in mice with ADAM8 inactivated
نویسندگان
چکیده
منابع مشابه
Intervertebral Disc Tissues
Cartilagenous intervertebral discs separate adjacent vertebrae in the spine, allowing modest spinal movements, and distributing compressive load evenly on the vertebral bodies. A central fluid-like nucleus pulposus region is surrounded by a tough laminated annulus fibrosus. Because adult discs lack a blood or nerve supply, cell density is very low and tissue turnover is very slow. Consequently,...
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BACKGROUND Intervertebral disc (IVD) disease is a common spinal disorder in dogs and degeneration and inflammation are significant components of the pathological cascade. Only limited studies have studied the cytokine and chemokine profiles in IVD degeneration in dogs, and mainly focused on gene expression. A better understanding is needed in order to develop biological therapies that address b...
متن کاملElastic tissues of the intervertebral disc.
Elastic fibres have been generally considered to play no significant role in the mechanical functioning of the intervertebral disc since earlier studies reported that the elastic fibre network was sparse and irregular. However, a recent study has reported that the network is highly organized and that the distribution and orientation of elastic fibres varies from region to region. In the annulus...
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Introduction: Low back pain is a condition that affects 11 million people in the UK alone and is a huge economic burden. Many cases can be attributed to degeneration of the intervertebral disc (IVD), an age-related process that involves structural, mechanical, cellular and molecular changes in the disc. Importantly, changes in cellular activity such as decreased proteoglycan production and incr...
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INTRODUCTION: Lubricin, also called superficial zone protein (SZP) or Proteoglycan 4 (PRG4), was first identified as the boundary lubricant in synovial fluid. In diarthrodial joints, lubricin is produced by superficial zone chondrocytes and synovial lining cells. It is present in the superficial layer of articular cartilage and coats the articular surface, decreasing surface friction. Lubricin ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-021-81495-y